Proceedings from the International Symposium on Antibiotic Resistance 1979, the fourth volume in the series of material edited from the Smolenice symposium, is a continuation in the tradition of communicating new scientific results on a currently important and interesting problem. It concerns not only human and veterinary medicine and practice, but also such important fields of contemporary biology as molecular biology and genetics. Indeed, in both these disciplines, we have recently noted a strong and dynamic de velopment of scientific knowledge directed toward such outgrowths of the study of plasmids as gene manipulations, transposons, and transposition, as well as the evolution of plasmids in general. Because of a very real global development of resistance to the newest antibiotics, and the active participation of experts from medical science and practice, it was reasonable to separate the medical part of the program from the theoretical one. Consequently, priorities of the fourth symposium were transposons and the transposition of resistance of to antibiotics, with their serious impact on epidemiology, the resistance of Pseudomonas aeruginosa, that is becoming a prominent nosocomial pathogen, the ecology and epidemiology ofR plasmids, and, last though not least, the computer-assisted surveillance of resistance to antibiotics.

I. Theoretical Part

Nonconjugative drug resistance plasmids
Genetic studies of nonconjugative sulfanilamide resistance plasmids in gram-negative bacteria
R plasmids and bacterial chromosome transfer
R 68.45, a plasmid with chromosome mobilizing ability differs from R68 by a duplicated DNA region
Mapping of replication genes of plasma RP4
Translocation of drug resistance genes in P. aeruginosa
Carbenicillin resistance and multiresistance plasmid in P. aeruginosa
Attempts to transduce antibiotic resistance in P. aeruginosa
Molecular and genetic analyses of plasmids responsible for lactose catabolism in Salmonellae isolated from diseased humans
The influence of the rec A mutation on the intramolecular gene amplification of Tn 1771 in Escherichia coli
Gene expression of transposable element determining ampicillin resistance
New recombinant prophages between bacteriophage P1 and the R plasmid NR 1
Promoters of replication determinants of plasmid R6-5
RP4 mutants generated by insertion element ISR1
A mutant affecting the deletion of resistance-determinant(s) on R plasmids
Plasmid R 1 contains two distinct functional replicons
Chromosomal mutation affecting the expression of plasmid R6K #x0394;1 in E. coli K-12
Isolation and characterization of temperature-sensitive mutants for replication of composite plasmid Rms 201
Genetic and physico-chemical analysis of antibiotic resistance plasmids of clinical strains
The properties of E. coli (R+)- strain with a mutation in the Rldrd-19 plasmid
Investigation about an eventual correlation between generation time of E. coli increased by R plasmids and their molecular size
Loss of the multi-copy resistance plasmid pBR 325 from E.coli GY 2354 pBR 325 during continuous cultivation
Isoelectricfocusing analysis of monoplasmids carried by E. coli strains
Enhanced chloramphenicol resistance of the lysogenic strain E. coli GY 2354 P1CM
Reassortment and gene amplification of R-factor R 1767 from Salmonella typhimurium
Characterization of A SmSuplasmid (rBP1) frequently occurring in clinical isolates of E. coli
Replication functions determined by the basic replicon of the antibiotic resistance factor R1
Cloning of synthesis and transport functions of the extracellular toxic protein, #x03B1;-haemolysin of E. coli
Molecular fine structure of enterotoxin plasmid obtained from E. coli and inserted with drug-resistance transposons
Conditions for the existance of R plasmids in bacterial populations
R-factor transfer under environmental conditions
Incompability testing of FI* R-factors from the area of Berne
II. Medical Part
In vitro and in vivo antibacterial activity of T-1551, a new semisynthetic Cephalosporin
In vitro susceptibility to cefamandole of staphylococci enterococci, Enterobacteriacae and Pseudomonas species
YM 09330, a new broad-spectrum semisynthetic Cephamycin antibiotic
Immunochemical properties of the structures of Salmonella typhimurium strains resistant to Cephaloridine
In vitro and in vivo antibacterila activity, beta-lactamase stability and binding affinity to penicillin-binding proteins of Cefotaxime (HR 756), a new Cephalosporin derivative
In vitro and in vivo antibacterial acitivity of AM-715, a new analog of Nalidixic ac id
Interactions of Azlocillin and Mezlocillin with aminoglycosides against Carbenicillin-resistant and sensitive P. aeruginosa
N. I. H. Programs in antibiotic resistance, recombinant DNA, hospital-associated infections and sexually transmitted diseases
The spread of Transposon 7 among bacteria of medical and veterinary importance
Trimethoprim resistance plasmids from Enterobacteriaceae isolated in Greece
Gentamicin resistance plasmids in hospital in flections
Drug resistance of Bordetella bronchiseptica from pigs
Antibiotic resistance and R plasmids in Serratia marcescens isolated from clinical specimens in Japan
AAC(3) and AAC (6?) enzymes produced by R plasmids isolated in general hospital
Inactivation of aminogycosides by enzymes: Biological properties of inactivation products
Structural and functional relationship between aminoglycoside-modifying enzymes from streptococci and staphylococci
Could a single enzyme inactivate aminoglycoside antibiotics by two different mechanisms
Multiple enzymatic modification of aminoglycosides by P. aeruginosa and enterobacteria strains resistant to gentamicin, netilmicin, tobramycin and aminkacin
Biochemical aspects of bacterial resistance to new beta-lactam drugs non hydrolyzable by beta-lactamases
Stability of the drug resistance of S. aureus under different conditions. Spontaneous loss of some plasmids in experimental conditions in vivo
Studies on the role of Col V plasmid in the pathogenicity of E. coli strains
Studies on R and Col plasmids in S. sonnei strains frequently isolated from outbreaks
R plasmid ecology in Salmonella in human gut
Drug resistance in main udder pathogens
Salmonella heidelberg penicillinase plasmids found during a nosocomial epidemic
Computerization of a clinical microbiology laboratory
Identification of specific antibiotic resistance mechanisms from routine susceptibility testing results
Clinical use of antibiotics, a nationwide computer study
Problems concerning multicenter studies on drug resistance
Author index.