Science of Synthesis: Houben-Weyl Methods of Molecular Transformations is the entirely new edition of the acclaimed reference series Houben-Weyl, the standard synthetic chemistry resource since 1909. This new edition is published in English and will comprise 48 volumes published between the years 2000 and 2008.

Science of Synthesis is a quality reference work developed by a highly esteemed editorial board to provide a comprehensive and critical selection of reliable organic and organometallic synthetic methods. This unique resource is designed to be the first point of reference when searching for a synthesis strategy.

• Contains the expertise of presently 400 leading chemists worldwide
• Critically evaluates the preparative applicability and significance of the synthetic methods
• Discusses relevant background information and provides detailed experimental procedures

For full information on the Science of Synthesis series, visit the Science of Synthesis Homepage

1;Science of Synthesis - Volume 20a: Three Carbon--Heteroatom Bonds: Acid Halides; Carboxylic Acids and Acid Salts;11.1;Title page;31.2;Imprint;51.3;Preface;61.4;Volume Editor's Preface;81.5;Overview;101.6;Table of Contents;121.7;Introduction;321.8;20.1 Product Class 1: Acid Halides;461.8.1;20.1.1 Product Subclass 1: Acid Fluorides;511.8.1.1;20.1.1.1 Synthesis of Product Subclass 1;521.8.1.1.1;20.1.1.1.1 Method 1: Fluorination of Carboxylic Acids;521.8.1.1.1.1;20.1.1.1.1.1 Variation 1: Treatment with 2,4,6-Trifluoro-1,3,5-triazine;521.8.1.1.1.2;20.1.1.1.1.2 Variation 2: Treatment with Tetramethylfluoroformamidinium Hexafluorophosphate;531.8.1.1.1.3;20.1.1.1.1.3 Variation 3: Treatment with N,N-Diethylaminosulfur Trifluoride or N,N-Bis(2-methoxyethyl)aminosulfur Trifluoride;541.8.1.1.1.4;20.1.1.1.1.4 Variation 4: Treatment with Pyridinium Poly(hydrogen fluoride)/Dicyclohexylcarbodiimide;561.8.1.1.1.5;20.1.1.1.1.5 Variation 5: Treatment with 1-Fluoro-N,N,2-trimethylprop-1-en-1-amine;571.8.1.1.2;20.1.1.1.2 Method 2: Reactions of Acid Chlorides with Fluoride Ion;581.8.1.1.3;20.1.1.1.3 Method 3: Reactions of Carboxylate Esters and Anhydrides with Hydrogen Fluoride or Hydrogen Fluoride/Pyridine;591.8.2;20.1.2 Product Subclass 2: Acid Chlorides;601.8.2.1;20.1.2.1 Synthesis of Product Subclass 2;611.8.2.1.1;20.1.2.1.1 Method 1: Chlorination of Carboxylic Acids;611.8.2.1.1.1;20.1.2.1.1.1 Variation 1: Treatment with Oxalyl Chloride;611.8.2.1.1.2;20.1.2.1.1.2 Variation 2: Treatment with Thionyl Chloride;641.8.2.1.1.3;20.1.2.1.1.3 Variation 3: Treatment with Triphenylphosphine/Carbon Tetrachloride and Other Phosphorus-Based Reagents;671.8.2.1.1.4;20.1.2.1.1.4 Variation 4: Treatment with 1-Chloro-N,N,2-trimethylprop-1-en-1-amine;691.8.2.1.1.5;20.1.2.1.1.5 Variation 5: Treatment with Bis(trichloromethyl) Carbonate;701.8.2.1.1.6;20.1.2.1.1.6 Variation 6: Treatment with 2,4,6-Trichloro-1,3,5-triazine;711.8.2.1.2;20.1.2.1.2 Method 2: Chlorination of Trialkylsilyl Carboxylate Esters;721.8.3;20.1.3 Product Subclass 3: Acid Bromides;731.8.3.1;20.1.3.1 Synthesis of Product Subclass 3;741.8.3.1.1;20.1.3.1.1 Method 1: Reactions of Carboxylic Acids with Phosphorus Tribromide;741.8.3.1.2;20.1.3.1.2 Method 2: Reactions of Carboxylic Acids or Trialkylsilyl Carboxylate Esters with Dibromotriphenylphosphorane;741.8.3.1.3;20.1.3.1.3 Method 3: Reactions of Carboxylic Acids with 1-Bromo-N,N,2-trimethylprop-1-en-1-amine;761.8.3.1.4;20.1.3.1.4 Method 4: Halide-Exchange Reactions of Acid Chlorides;771.8.3.1.5;20.1.3.1.5 Method 5: Oxidation of Aldehydes;781.8.4;20.1.4 Product Subclass 4: Acid Iodides;781.8.4.1;20.1.4.1 Synthesis of Product Subclass 4;791.8.4.1.1;20.1.4.1.1 Method 1: Synthesis from Acid Chlorides;791.8.4.1.2;20.1.4.1.2 Method 2: Synthesis from Carboxylate Esters;801.9;20.2 Product Class 2: Carboxylic Acids;1061.9.1;20.2.1 Product Subclass 1: Alkanoic Acids;1061.9.1.1;20.2.1.1 Synthesis from Carbonic Acid Derivatives;841.9.1.1.1;20.2.1.1.1 Method 1: Reactions with Carbon Dioxide;841.9.1.1.1.1;20.2.1.1.1.1 Variation 1: Reaction with Unstabilized Organometallic Carbanions;851.9.1.1.1.2;20.2.1.1.1.2 Variation 2: Reaction with Benzylic Carbanions;891.9.1.1.1.3;20.2.1.1.1.3 Variation 3: Reaction with Allylic and Propargylic Carbanions;931.9.1.1.1.4;20.2.1.1.1.4 Variation 4: Reaction with a-Heteroatom-Stabilized Carbanions;941.9.1.1.1.5;20.2.1.1.1.5 Variation 5: Electrochemical Carboxylations;971.9.1.1.1.6;20.2.1.1.1.6 Variation 6: Miscellaneous Carboxylations with Carbon Dioxide;1001.9.1.1.2;20.2.1.1.2 Method 2: Use of Other Carbonic Acid Derivatives;1011.9.1.2;20.2.1.2 Synthesis from Carboxylic Acid Derivatives;1061.9.1.2.1;20.2.1.2.1 Method 1: Hydrolysis of Acid Halides;1061.9.1.2.2;20.2.1.2.2 Method 2: Hydrolysis of Acid Anhydrides;1071.9.1.2.3;20.2.1.2.3 Method 3: Hydrolysis of Esters;1071.9.1.2.3.1;20.2.1.2.3.1 Variation 1: Base-Catalyzed Hydrolysi