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1. An Introduction to Transcription Factors.- Mechanisms of Transcriptional Activation in Eukaryotes.- Multiple Mechanisms of Transcriptional Repression in Eukaryotes.- Genomic Approaches to the Study of Transcription Factors.- 2. Transcription Factors in Pathophysiology.- Biological Roles of the STAT Family in Cytokine Signaling.- Members of the T-Cell Factor Family of DNA-Binding Proteins and Their Roles in Tumorigenesis.- Transcription Factors in the Control of Tumor Development and Progression by TGF-? Signaling.- The p53 Transcription Factor as Ther apeutic Target in Cancer.- The Role of Ets Transcription Factors in Mediating Cellular Transformation.- Function of the E2F Transcription Factor Family During Normal and Pathological Growth.- c-Myc in Cellular Transformation and Cancer.- NF-?B: Critical Regulator of Inflammation and the Immune Response.- Hepatitis BVirus X Protein: Structure-Function Relationships and Role in Viral Pathogenesis.- Regulation of Xenobiot ic Detoxification by PXR, CAR, GR, VDR and SHP Receptors: Consequences in Physiology.- 3. Exogenous Control of Transcription Factor Activity.- Potential of Transcription Factor Decoy Oligonucleotides as Therapeutic Approach.- Selective Estrogen Receptor Modulators as Therapeutic Agents in Breast Cancer Treatment.- Artificial Zinc Finger Peptides: A Promising Tool in Biotechnology and Medicine.- Tetracycline-Controlled Transactivators and Their Potential Use in Gene Therapy Applications.- Modulating Transcript ion with Artificial Regulators.

1. An Introduction to Transcription Factors
Mechanisms of Transcriptional Activation in Eukaryotes
Multiple Mechanisms of Transcriptional Repression in Eukaryotes
Genomic Approaches to the Study of Transcription Factors
2. Transcription Factors in Pathophysiology
Biological Roles of the STAT Family in Cytokine Signaling
Members of the T-Cell Factor Family of DNA-Binding Proteins and Their Roles in Tumorigenesis
Transcription Factors in the Control of Tumor Development and Progression by TGF-? Signaling
The p53 Transcription Factor as Ther apeutic Target in Cancer
The Role of Ets Transcription Factors in Mediating Cellular Transformation
Function of the E2F Transcription Factor Family During Normal and Pathological Growth
c-Myc in Cellular Transformation and Cancer
NF-?B: Critical Regulator of Inflammation and the Immune Response
Hepatitis BVirus X Protein: Structure-Function Relationships and Role in Viral Pathogenesis
Regulation of Xenobiot ic Detoxification by PXR, CAR, GR, VDR and SHP Receptors: Consequences in Physiology
3. Exogenous Control of Transcription Factor Activity
Potential of Transcription Factor Decoy Oligonucleotides as Therapeutic Approach
Selective Estrogen Receptor Modulators as Therapeutic Agents in Breast Cancer Treatment
Artificial Zinc Finger Peptides: A Promising Tool in Biotechnology and Medicine
Tetracycline-Controlled Transactivators and Their Potential Use in Gene Therapy Applications
Modulating Transcript ion with Artificial Regulators.
ISBN 978-3-540-21095-5
Medientyp Buch
Copyrightjahr 2004
Verlag Springer, Berlin
Umfang X, 581 Seiten
Abbildungen X, 581 p.
Sprache Englisch