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This volume attempts to summarize the current state of knowledge on mechanisms underlying the various effects of analgesics, their side effect profiles, and their indications and contraindications in clinical use. It also gives insights into current efforts to discover novel mechanisms underlying the generation of different types of pain and the resulting development of new modulating compounds.

1;Preface;5 2;List of Contents;6 3;List of Contents;6 4;List of Contributors;8 5;I Introduction;9 5.1;Peripheral and Central Mechanisms of Pain Generation;10 6;II Drugs in Clinical Use;36 6.1;Opioids;37 6.2;Antipyretic Analgesics: Nonsteroidal Antiinflammatory Drugs, Selective COX- 2 Inhibitors, Paracetamol and Pyrazolinones;70 6.3;Local Anesthetics;99 6.4;Serotonin Receptor Ligands: Treatments of AcuteMigraine and Cluster Headache;132 6.5;Anti-convulsants and Anti-depressants;147 7;III Compounds in Preclinical Development;180 7.1;Neuropeptide and Kinin Antagonists;181 7.2;Glutamate Receptor Ligands;217 7.3;Adrenergic and Cholinergic Compounds;250 7.4;Cannabinoids and Pain;264 8;IV Future Targets in Analgesia Research;306 8.1;Adenosine and ATP Receptors;307 8.2;Ion Channels in Analgesia Research;327 8.3;Protein Kinases as Potential Targets for the Treatment of Pathological Pain;357 9;V Pain Management Beyond Pharmacotherapy;388 9.1;Placebo and Endogenous Mechanisms of Analgesia;389 9.2;Heart;395 9.3;Limitations of Pharmacotherapy: Behavioral Approaches to Chronic Pain;410 10;Subject Index;423
ISBN 9783540338239
Artikelnummer 9783540338239
Medientyp E-Book - PDF
Auflage 2. Aufl.
Copyrightjahr 2007
Verlag Springer-Verlag
Umfang 435 Seiten
Sprache Englisch
Kopierschutz Digitales Wasserzeichen