This volume contains a unique selection of chapters covering a wealth of contemporary topics in this ubiquitous and diverse system of cell signaling. It offers much more than the accessibility and authority of a primary text book, exploring topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to bacteria, fruit fly and zebrafish. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative.
The chapter "Calcium Signaling: From Basic to Bedside" is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Preface

Calcium signaling: from basics to bedside
Measuring Ca²⁺ in living cells
High-throughput fluorescence assays for Ion Channels and GPCRs
Imaging Native Calcium Currents in Brain Slices
Molecular diversity of plasma membrane Ca²⁺ transporting ATPases: their function under normal and pathological conditions
A role for SERCA pumps in the neurobiology of neuropsychiatric and neurodegenerative disorders
Cytoplasmic Calcium Buffering: An Integrative Crosstalk
An update on calcium binding proteins
Manuel  Campos-Toimil
New insights in the IP₃ receptor and its regulation
Expression of the inositol 1,4,5-trisphosphate receptor and the ryanodine receptor Ca²⁺-release channels in the beta-cells and alpha- cells of the human islets of Langerhans
Evolution of Excitation-Contraction Coupling
Molecular Insights into Calcium Dependent Regulation of Ryanodine Receptor Calcium Release Channels
Sarco-endoplasmic reticulum calcium release model based on changes in the luminal calcium content visualized from the luminal side
Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores
Calcium Signaling in the Heart
Molecular basis and regulation of store-operated calcium entry
Structure and activation mechanisms of CRAC channels
Canonical Transient Potential Receptor-3 Channels in Normal and Diseased Airway Smooth Muscle Cells
Pathophysiological significance of store-operated calcium entry in cardiovascular and skeletal muscle disorders and angiogenesis
Calcium signalling and the regulation of chemosensitivity in cancer cells: role of the Transient Receptor Potential channels
Targeting Transient Receptor Potential Channels by microRNAs drives tumor development and progression
Calcium channels and Calcium-regulated channels in human red blood cells
Regulation of multifunctional calcium/calmodulin stimulated protein kinases by molecular targeting
Widespread roles of CaMK-II in Developmental Pathways
Readily releasable stores of calcium in neuronal endolysosomes: Physiological and pathophysiological relevance
At the crossing of ER stress and MAMs: A key role of Sigma-1 receptor?- ER-mitochondria calcium transfer, organelle contacts and neurodegenerative diseases
The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells
Calcium Signaling and Gene Expression
Simulation Strategies for Calcium Microdomains and Calcium Noise
A statistical view on calcium oscillations
Calcium Regulation of Bacterial Virulence
Ca²⁺ Signaling in Drosophila Photoreceptor Cells
Calcium imaging in Drosophila melanogaster
Calcium imaging in the zebrafish
Stimulation-secretion coupling in the beta cells: from basic to bedside
Calcium dynamics and synaptic plasticity
Calcium signaling during brain aging and its influence on the hippocampal synaptic plasticity
Calcium Signaling in Endothelial Colony Forming Cells in Health and Disease
Sensing Extracellular Calcium - An Insight into the Structure and Function of the Calcium-Sensing Receptor (CaSR)
Extracellular Ca²⁺ in bone marrow
Calcium in Cell-Extracellular Matrix Interactions
Index.