Few medical or scientific addresses have so unmistakeably made history as the presentation delivered by Alois Alzheimer on November 4, 1906 in Tübingen.

The celebratory event, "Alzheimer 100 Years and Beyond" organized on the initiation of the Alzheimer community in Germany and worldwide, in collaboration with the Fondation Ipsen, was the highlight of the Year of Alzheimer. However, beyond these few months of tributes, the centennial offers a unique opportunity to assess both the progress achieved and the uncertainties remaining. This volume, a collection comprised mainly of articles by the invited speakers and also of a few other prominent researchers, is meant to be a record of those events.

Alois Alzheimer

Concerning a unique disease of the cerebral cortex
The history of Alois Alzheimer's first case Auguste D.
Alois Alzheimer and the beginnings of research into Alzheimer's disease
Alois Alzheimer and the myth of the pioneer
The beginning of modern research
Alzheimer's Disease at mid-Century (1927-1977) and a little more
A chapter in the development on Alzheimer's disease research
Anatomy & Neuropsychology
Anatomical changes underlying dementia in Alzheimer's disease
Staging of cortical neurofibrillary inclusions of the Alzheimer's type
Of stains and brains: a brief account of how microscopic and clinical observations contributed to the understanding of Alzheimer's disease
Presenile forms of Alzheimer's disease in 2006
Cholinergic Deficit
The cholinergic deficit in Alzheimer's disease
Acetylcholine in AD: Expectations meet reality
Amyloid and Genetics
The Discovery of ? Amyloid
Pathways to the discovery of the neuronal origin and proteolytic biogenesis of A? amyloid of Alzheimer's disease
The Amyloid Hypothesis: history and alternatives
Segregation of a missense mutation in the amyloid ?-protein precursor gene with familial Alzheimer's disease
From the amyloid ? protein (A4) to isolation of the first Alzheimer's disease gene: amyloid ? (A4) precursor protein (APP)
Commentary on "Correlative memory deficits, A? elevation, and amyloid plaques in transgenic mice"
Vision for the future
PS1, PS2, and APP mutations that cause Alzheimer's disease increase A?42
Amyloid precursor protein, Alzheimer's disease, and Down's syndrome
Catabolism of amyloid ? peptide and pathogenesis of sporadic Alzheimer's disease: towards understanding the underlying mechanisms.-Synaptic activity, amyloid-? and Alzheimer's disease
Molecular pathogenesis of Alzheimer's disease in human peripheral cells: platelets show it all!
The neuronal origin hypothesis of cerebral amyloid angiopathy
A neuropathologist and Alzheimer genetics
Genetics, molecular biology, and animal modeling of Alzheimer's disease
The genetic Alzheimer-frontotemporal dementia spectrum
Mutation of the Alzheimer's disease amyloid gene in hereditary cerebral hemorrhage, Dutch type. The role of amyloid in dementia and stroke
Physiological generation of Amyloid ?-peptide and its Consequences for Alzheimer's disease research
Activation of ?-secretase as an approach for treatment of Alzheimer's disease
Challenges to the enigma of ?-secretase and to Alzheimer's disease
Targeting ?-Secretase for Alzheimer's Disease
The Presenilin/gamma-secretase complex and its potential as a drug target in Alzheimer's Disease
Identification of ?-secretase
ApoE
Apolipoprotein E and Alzheimer's disease: A brief retrospective
Apolipoprotein E4: From synaptic remodeling to genetic risk factor in both familial and sporadic Alzheimer's disease
Tau
The Alzheimer tangle - 100 years on.
Immunological demonstration of tau protein in neurofibrillary tangles
Bulk isolation of neurofibrillary tangles and discoveries of tau and its abnormal hyperphosphorylation
The natural and molecular history of Alzheimer's disease: Tau is part of the story
Tau focused drug discovery for Alzheimer's disease and related Neurodegenerative Tauopathies
Ubiquitin is a component of paired helical filaments in Alzheimer's disease
Influence of tau on neuronal traffic mechanisms
The Search for structure of tau and paired helical filaments
OxidativeStress
The Changing landscape of Alzheimer's disease: From Insoluble to Soluble and from Pathogen to Protector
Molecular and cellular pathways towards and away from Alzheimer's disease
Epidemiology
Paquid: an integrated, multidisciplinary, population-based approach to normal and pathological cerebral aging
Imaging
Hippocampal imaging in the early diagnosis of AD, 1988 to 2006
Detecting Early-Stage Alzheimer's Disease in MCI and PreMCI: The value of informants
Imaging the pathology of Alzheimer's disease: Building on a century-Old blueprint
Therapeutical Perspectives
How do we test drugs?
Inflammation and the lesions of Alzheimer's disease
A? immunotherapy prevents and Reverses Alzheimer's disease neuropathology
Immunotherapy of Alzheimer's disease
"Magic" bullets, shotguns or cocktails to treat or prevent Alzheimer's disease?
The seventh age of man: Solving senility
Forum and Network
Fondation Ipsen and Alzheimer's disease: a 20-year relationship
Alzheimer Research Forum: A Knowledge Base and e-Community for AD Research.